MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000358

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.

Identifieur interne : 000358 ( Main/Exploration ); précédent : 000357; suivant : 000359

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.

Auteurs : Khalid El Bairi [Maroc] ; Abdul Hafeez Kandhro [Pakistan] ; Adel Gouri [Algérie] ; Wafaa Mahfoud [Maroc] ; Noureddine Louanjli [Maroc] ; Brahim Saadani [Maroc] ; Said Afqir [Maroc] ; Mariam Amrani [Maroc]

Source :

Cellular oncology (Dordrecht) [ 2211-3436 ] ; 2017.

RBID : pubmed:27981507

Descripteurs français

KwdFr :
- Cellules tumorales circulantes (anatomopathologie), Femelle (MeSH), Humains (MeSH), Marqueurs biologiques tumoraux (sang), Modèles biologiques (MeSH), Pronostic (MeSH), Tumeurs de l'ovaire (anatomopathologie), Tumeurs de l'ovaire (diagnostic), Tumeurs de l'ovaire (génétique), Tumeurs de l'ovaire (thérapie), Épigenèse génétique (MeSH).
MESH :
- anatomopathologie : Cellules tumorales circulantes, Tumeurs de l'ovaire.
- diagnostic : Tumeurs de l'ovaire.
- génétique : Tumeurs de l'ovaire.
- sang : Marqueurs biologiques tumoraux.
- thérapie : Tumeurs de l'ovaire.
- Femelle, Humains, Modèles biologiques, Pronostic, Épigenèse génétique.

English descriptors

KwdEn :
- Biomarkers, Tumor (blood), Epigenesis, Genetic (MeSH), Female (MeSH), Humans (MeSH), Models, Biological (MeSH), Neoplastic Cells, Circulating (pathology), Ovarian Neoplasms (diagnosis), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Ovarian Neoplasms (therapy), Prognosis (MeSH).
MESH :
- chemical , blood : Biomarkers, Tumor.
- diagnosis : Ovarian Neoplasms.
- genetics : Ovarian Neoplasms.
- pathology : Neoplastic Cells, Circulating, Ovarian Neoplasms.
- therapy : Ovarian Neoplasms.
- Epigenesis, Genetic, Female, Humans, Models, Biological, Prognosis.

Abstract

BACKGROUND

In spite of various treatment options currently available, ovarian cancer (OC) still remains a leading cause of death in women world-wide. Diagnosis at an early stage is one of the most important factors that determines survival. Current clinical diagnostic tools have, however, a limited efficacy in early OC detection. Therefore, there is a critical need for new (early) diagnostic biomarkers and tools. Through advances in genomic, proteomic and metabolomic techniques, several novel molecular OC biomarkers have recently been identified. These biomarkers are currently subject to validation. In addition, integration of genomic, proteomic and metabolomic data, in conjunction with epidemiologic and clinical data, is considered essential for obtaining useful results. Interesting recent work has already shown that specific diagnostic biomarkers, such as BRCA mutations, may have profound therapeutic implications. Here, we review the current state of OC research through literature and database searches, with a focus on various recently identified biomarkers via different technologies for the (early) diagnosis, prognosis and treatment of OC.

CONCLUSIONS

Multi-biomarker panels accompanied by a meticulous determination of their sensitivity and specificity, as well their validation, using multivariate analyses will be critical for its clinical application, including early OC detection and tailor-made OC treatment.

DOI: 10.1007/s13402-016-0309-1
PubMed: 27981507

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers, Tumor (blood)</term>
<term>Epigenesis, Genetic (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Models, Biological (MeSH)</term>
<term>Neoplastic Cells, Circulating (pathology)</term>
<term>Ovarian Neoplasms (diagnosis)</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Ovarian Neoplasms (pathology)</term>
<term>Ovarian Neoplasms (therapy)</term>
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<term>Humains (MeSH)</term>
<term>Marqueurs biologiques tumoraux (sang)</term>
<term>Modèles biologiques (MeSH)</term>
<term>Pronostic (MeSH)</term>
<term>Tumeurs de l'ovaire (anatomopathologie)</term>
<term>Tumeurs de l'ovaire (diagnostic)</term>
<term>Tumeurs de l'ovaire (génétique)</term>
<term>Tumeurs de l'ovaire (thérapie)</term>
<term>Épigenèse génétique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers, Tumor</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules tumorales circulantes</term>
<term>Tumeurs de l'ovaire</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Ovarian Neoplasms</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs de l'ovaire</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ovarian Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs de l'ovaire</term>
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<term>Ovarian Neoplasms</term>
</keywords>
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</keywords>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In spite of various treatment options currently available, ovarian cancer (OC) still remains a leading cause of death in women world-wide. Diagnosis at an early stage is one of the most important factors that determines survival. Current clinical diagnostic tools have, however, a limited efficacy in early OC detection. Therefore, there is a critical need for new (early) diagnostic biomarkers and tools. Through advances in genomic, proteomic and metabolomic techniques, several novel molecular OC biomarkers have recently been identified. These biomarkers are currently subject to validation. In addition, integration of genomic, proteomic and metabolomic data, in conjunction with epidemiologic and clinical data, is considered essential for obtaining useful results. Interesting recent work has already shown that specific diagnostic biomarkers, such as BRCA mutations, may have profound therapeutic implications. Here, we review the current state of OC research through literature and database searches, with a focus on various recently identified biomarkers via different technologies for the (early) diagnosis, prognosis and treatment of OC.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Multi-biomarker panels accompanied by a meticulous determination of their sensitivity and specificity, as well their validation, using multivariate analyses will be critical for its clinical application, including early OC detection and tailor-made OC treatment.</p>
</div>
</front>
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Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki